| 对羟基苯乙酮的合成研究 |
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| 引用本文： | 张正,杨盟辉,段远富. 对羟基苯乙酮的合成研究[J]. 化学工程师, 2010, 24(10): 55-56 |
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| 作者姓名： | 张正 杨盟辉 段远富 |
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| 作者单位： | 中国人民解放军61788部队,湖北,武汉,430070;中国人民解放军61788部队,湖北,武汉,430070;中国人民解放军61788部队,湖北,武汉,430070 |
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| 摘 要： | 以苯甲醚、乙酰氯为原料,AlCl3为催化剂通过Friedel-Crafts酰基化反应和脱甲基化两步反应得到对羟基苯乙酮。考查了反应时间、反应温度等条件对反应的影响,确定了反应的最佳条件。在最佳工艺条件下对羟基苯乙酮的总收率为65%,经熔点和红外光谱表征与目标化合物的结构一致。
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| 关 键 词： | 对羟基苯乙酮 Friedel-Crafts酰基化 脱甲基化 合成 |
Research on synthesis of p-hydroxyacetophenone |
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| ZHANG Zheng,YANG Meng-hui,DUAN Yuan-fu. Research on synthesis of p-hydroxyacetophenone[J]. Chemical Engineer, 2010, 24(10): 55-56 |
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| Authors: | ZHANG Zheng YANG Meng-hui DUAN Yuan-fu |
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| Affiliation: | (Unit No.61788,People＇s Liberation Army,Wuhan 430070,China) |
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| Abstract: | The p-hydroxyacetophenoen was synthesized from anisole,acetyl chloride as starting materials and AlCl3 as catalyst through Friedel-Crafts acylation and demethylation.The influence factors of reaction time and reaction temperature were studied,and the optimal reaction conditions were obtained.The total yield of p-hydroxyacetophenoen was 65%.The result was confirmed by melting point and infrared spectrum. |
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| Keywords: | p-hydroxy phenone Friedel-Crafts acylation demethy lation synthesis |
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