抗痛风药非布索坦的合成工艺优化

以2-（3-甲酰基-4-异丁氧基一苯基）-4-甲基-噻唑-5-甲酸乙酯为原料，经醛肟脱水、水解制备非布索坦，并对其工艺进行了优化。合成的非布索坦纯度达到99％以上，单个杂质不超过0．1％，总收率达63．31％。优化后的工艺简单易控，产品纯度及收率较高，达到药用标准。

Optimization of Synthetic Process of Anti-Gout Drug Febuxostat

With ethyl 2-（3-formyl-4-isobutoxyphenyl）-4-methylthiazole-5-carboxylate as raw material, fe- buxostat was synthesized through the hindered dehydration and the latter hydrolysis reaction,and the process was optimized. The febuxostat was obtained with purity over 99% ,single impurity not exceeding 0.1% and to- tal yield, 63.31%. The optimized process was simple and easy to control with high purity and yield, the product met the requirement of medical standard.