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A versatile strategy to construct surface functionalized pH/redox dual stimuli-responsive nanogels for targeted drug delivery |
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| Authors: | Zhao Wang Jiajian Shi Mengyao Gu Xiaojuan Zhang Ruilong Sheng |
| Affiliation: | 1. School of Material Engineering, Jinling Institute of Technology, Nanjing, China;2. School of Material Engineering, Jinling Institute of Technology, Nanjing, China
Jinling Institute of Technology, Nanjing Key Laboratory of Optometric Materials and Technology, Nanjing, China Contribution: Conceptualization (supporting), Data curation (supporting), Formal analysis (supporting), Investigation (supporting), Methodology (supporting), Writing - original draft (supporting);3. School of Material Engineering, Jinling Institute of Technology, Nanjing, China Jinling Institute of Technology, Nanjing Key Laboratory of Optometric Materials and Technology, Nanjing, China Contribution: Data curation (supporting), Formal analysis (supporting), Investigation (supporting), Methodology (supporting), Writing - original draft (supporting);4. School of Material Engineering, Jinling Institute of Technology, Nanjing, China Jinling Institute of Technology, Nanjing Key Laboratory of Optometric Materials and Technology, Nanjing, China Contribution: Formal analysis (supporting), Investigation (supporting), Methodology (supporting), Writing - review & editing (supporting);5. CQM-Centro de Quimica da Madeira, Universidade da Madeira, Campus da Penteada, Funchal, Madeira, Portugal |
| Abstract: | Developing facile, green, and efficient synthetic methodology for preparing surface-functionalized nanogels has attracted tremendous attention in the field of polymer chemistry and biomaterials engineering. Herein, a series of “clickable” P(MAA-PMA) nanogels with reactive alkyne groups were conveniently prepared by “one-pot” reflux-precipitation polymerization (RPP), their particle sizes and zeta potentials are solid content-dependent. Using P(MAA-PMA)-1 nanogels as the model, the physicochemical properties including particle size, surface potential, morphology, solution stability, and pH/redox responsiveness were characterized in detail. Moreover, the pH/redox dual-responsive drug release feature/kinetics and parameters were analyzed using Korsmeyer–Peppas model and Gallagher–Corrigan model. Then the surface of nanogels was facilely modified with various thiol-containing functional ligands via thiol-yne photo click reaction. As targeted drug carriers, doxorubicin (DOX)-loaded folic acid (FA)-functionalized nanogels (FA@Nanogels/DOX) demonstrated higher tumor cell proliferation inhibition effect in B16F10 cancer cells than that in CHO-K1 normal cells, while the non-FA-functionalized counterparts (Nanogels/DOX) do not show similar effect. This work provides a versatile “one-pot RPP-photo Click functionalization” strategy to construct surface-functionalized pH/redox dual responsive nanogels for efficient and targeted drug delivery. |
| Keywords: | drug delivery folic acid pH/redox dual responsive reflux-precipitation polymerization targeting thiol-yne photo click reaction |