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Study on the gelation and sustained release effect of the thermosensitive material TPGS1000 |
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| Authors: | Suna He Ziqin Yang Xingyue Qian Wanting He Chen Li |
| Affiliation: | 1. Department of Pharmaceutical Sciences, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, People's Republic of China;2. Clinical Medicine, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, People's Republic of China
Contribution: Data curation (equal), Project administration (lead), Writing - original draft (equal);3. Department of Pharmaceutical Sciences, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, People's Republic of China Contribution: Project administration (supporting), Validation (equal), Writing - review & editing (equal);4. Department of Pharmaceutical Sciences, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, People's Republic of China Contribution: Software (lead), Validation (equal), Writing - review & editing (equal) |
| Abstract: | Polyethylene glycol 1000 vitamin E succinate (TPSG1000) was commonly used as absorption promoter, solubilizer, and emulsifier in drug delivery systems. In addition, TPGS1000 possessed thermosensitivity and gelling property that were not extensively studied. Hence, TPGS1000 was synthesized by Collnot method, characterized, evaluated for gelling property, and applied as the thermosensitive carrier in the study. Thin-layer chromatography, Fourier transform infrared spectroscopy, and high-performance liquid chromatography methods proved that the TPGS1000 was successfully synthesized. Under the condition of 4.5% sodium sulfate, 12% TPGS1000 could rapidly form stable hydrogels at 37°C. In addition, the gelling time tends to shorten with temperature increasing. It is worth noting that TPGS1000 as the carrier for loading doxorubicin displayed significant sustained release behavior. In conclusion, the study laid foundation for the application and further research of TPGS1000 in thermosensitive gel drug delivery system and provides a novel material for thermosensitive gel preparations. |
| Keywords: | drug release gelling property thermosensitive gel TPGS1000 |