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Chlorinative Cyclization of 1,6‐Enynes by Enantioselective Palladium(II)/Palladium(IV) Catalysis |
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| Authors: | Kazuhiro Takenaka Shintaro Hashimoto Shinobu Takizawa Hiroaki Sasai |
| Abstract: | A novel asymmetric catalysis via a palladium(II)/palladium(IV) cycle has been developed by utilizing a chiral spiro bis(isoxazoline) ligand (SPRIX). Intramolecular chlorinative cyclization of 1,6‐enynes catalyzed by a palladium‐SPRIX complex proceeded enantioselectively to afford α‐methylene‐γ‐lactone derivatives. |
| Keywords: | asymmetric catalysis cyclization enynes lactones palladium(II)/palladium(IV) cycle |