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A Novel Assembly of Substituted Pyrroles by Acid‐Catalyzed Sequential Three‐Component Reaction of Amines,Alkynoates, and 1,2‐Diaza‐1,3‐dienes |
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| Authors: | Orazio A Attanasi Gianfranco Favi Fabio Mantellini Giada Moscatelli Stefania Santeusanio |
| Abstract: | A novel protocol for the assembly of polysubstituted pyrroles has been developed through the acid‐catalyzed, sequential three‐component reaction of primary aliphatic amines, alkynoates and 1,2‐diaza‐1,3‐dienes (DDs). This methodology proceeds with complete chemo‐/regioselectivity involving first formation of an enamino ester intermediate, in situ Michael addition with azo‐ene compounds and subsequent intramolecular ring closure. |
| Keywords: | 1 2‐diaza‐1 3‐dienes Michael addition pyrroles regioselectivity sequential reactions |