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Organocatalytic Highly Enantioselective Synthesis of β‐Formyl‐α‐hydroxyphosphonates
Authors:Sandun Perera  Vijaya Kumar Naganaboina  Long Wang  Bin Zhang  Qunsheng Guo  Laxmidhar Rout  Cong‐Gui Zhao
Abstract:The cross‐aldol reaction between enolizable aldehydes and α‐ketophosphonates was achieved for the first time by using 9‐amino‐9‐deoxy‐epi‐quinine as the catalyst. β‐Formyl‐α‐hydroxyphosphonates were obtained in high to excellent enantioselectivities. The reaction works especially well with acetaldehyde, which is a tough substrate for organocatalyzed cross‐aldol reactions. The products were demonstrated to have anticancer activities.
Keywords:aldehydes  hydroxyphosphonates  ketophosphonates  organocatalysis  primary amines
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