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Organocatalytic Asymmetric α‐Amination of Unprotected 3‐Aryl and 3‐Aliphatic Substituted Oxindoles using Di‐tert‐butyl Azodicarboxylate |
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| Authors: | Feng Zhou Miao Ding Yun‐Lin Liu Cui‐Hong Wang Cong‐Bin Ji Yi‐Yu Zhang Jian Zhou |
| Abstract: | The bifunctional quinine‐derived thiourea catalyst 14 was found to catalyze the direct amination of unprotected 3‐aryl and aliphatic substituted oxindoles with di‐tert‐butyl azodicarboxylate (DBAD) to construct a tetrasubstituted stereogenic carbon center at the C‐3 position of oxindoles in good to excellent yield and enantioselectivity. |
| Keywords: | 3‐aminooxindoles asymmetric catalysis atom efficiency organocatalysis tetrasubstituted stereogenic carbon centers |