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Palladium‐Catalyzed Allylic Alkylation of Doubly Deprotonated Carboxylic Acids |
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| Authors: | Manfred Braun Panos Meletis Robin Visse |
| Abstract: | Doubly deprotonated carboxylic acids undergo smooth palladium‐catalyzed carbon alkylations with the allylic substrates methyl allyl carbonate and (E)‐methyl (pent‐3‐en‐2‐yl) carbonate to give γ,δ‐unsaturated carboxylic acids. A diastereoselective and enantioselective protocol leads to (2S,3R)‐hexenoic acid in 87% ee. |
| Keywords: | allylation lithium stereoselectivity synthetic methods |