Asymmetric Epoxidation of α,β‐Unsaturated Aldehydes in Aqueous Media Catalyzed by Resin‐Supported Peptide‐ Containing Unnatural Amino Acids |
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Authors: | Kengo Akagawa Kazuaki Kudo |
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Abstract: | The enantio‐ and diastereoselective epoxidation of α,β‐unsaturated aldehydes in aqueous media was realized using a resin‐supported peptide catalyst. Introducing the hydrophobic and bulky unnatural amino acid 3‐(1‐pyrenyl)alanine into the peptide sequence was effective for enhancing the reaction rate and enantioselectivity. |
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Keywords: | aqueous‐phase catalysis asymmetric catalysis epoxidation immobilization peptides proline |
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