Protection of mice against Plasmodium yoelii sporozoite challenge with P. yoelii merozoite surface protein 1 DNA vaccines |
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| Authors: | SI Becker R Wang RC Hedstrom JC Aguiar TR Jones SL Hoffman MJ Gardner |
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| Affiliation: | Malaria Program, Naval Medical Research Institute, Bethesda, Maryland 20889-5607, USA. |
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| Abstract: | Immunization of mice with DNA vaccines encoding the full-length form and C and N termini of Plasmodium yoelii merozoite surface protein 1 provided partial protection against sporozoite challenge and resulted in boosting of antibody titers after challenge. In C57BL/6 mice, two DNA vaccines provided protection comparable to that of recombinant protein consisting of the C terminus in Freund's adjuvant. |
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