首页 | 本学科首页   官方微博 | 高级检索  
     


Studies on the role of platelet-activating factor in blood pressure regulation
Authors:Katsuhiko Sakaguchi  Shigeto Morimoto  Fuminori Masugi  Shuichi Saeki  Toshio Ogihara  Kouji Yamada  Isao Yamatsu
Affiliation:(1) Department of Geriatric Medicine, Osaka University Medical School, Fukushima-ku, 553 Osaka, Japan;(2) Tsukuba Research Laboratories, Eisai Co., Ltd., 300-26 Tsukuba, Ibaraki, Japan
Abstract:Circulating levels of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (C16PAF) in human subjects were measured by gas chromatography/mass spectrometry using negative ion chemical ionization. The mean (±S.D.) circulating C16PAF levels in patients with essential hypertension (18.1±5.3 pg/mL, n=16) were not significantly different from those in normotensive subjects (17.2±7.2 pg/mL, n=14). During a salt balance study, high salt intake (20 g/day) significantly increased the circulating level of C16PAF, and changes in circulating C16PAF significantly and positively correlated with changes in mean arterial blood pressure (r=0.47, p<0.05). Changes in C16PAF also correlated with changes in creatinine clearance (r=0.55, p<0.05), but did not correlate with changes in plasma sodium concentration, plasma chloride concentration and plasma volume. An intravenous injection of 50 μg of human atrial natriuretic peptide (hANP) decreased circulating C16PAF levels from 20.0±2.7 to 13.9±2.4 pg/mL of blood (n=10, p<0.01) in healthy subjects. The data appear to indicate that C16PAF levels are changed by salt intake-induced mild increase in blood pressure, and that hANP may be an endogenous factor which lowers circulating C16PAF. Based on a paper presented at the Third International Conference on Platelet-Activating Factor and Structurally Related Alkyl Ether Lipids, Tokyo, Japan, May 1989.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号