Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer |
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Authors: | MV Agrez RC Bates D Mitchell N Wilson N Ferguson P Anseline D Sheppard |
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Affiliation: | Discipline of Surgical Science, Cancer Research Unit, John Hunter Hospital, Newcastle, Australia. |
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Abstract: | Current data from in vitro and in vivo animal models indicate that fibronectin-binding integrin receptors expressed by colon cancer cells may regulate tumour growth. While individual members of the beta 1 subfamily of integrins have now been clearly identified in colorectal cancer, little information exists with respect to the alpha V subfamily. In the present study we show that alpha V can associate with multiple and different beta subunits capable of binding fibronectin in this tumour type. This is likely to have functional implications for growth and spread of colorectal cancer. |
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