| 正常或轻度肾功能受损社区居民肾小球滤过率与动脉硬化的相关性 |
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| 引用本文： | 边素艳,叶平,盛莉,骆雷鸣,肖铁卉,祁莉萍,吴红梅,肖文凯,段留法. 正常或轻度肾功能受损社区居民肾小球滤过率与动脉硬化的相关性[J]. 压电与声光, 2010, 0(6) |
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| 作者姓名： | 边素艳 叶平 盛莉 骆雷鸣 肖铁卉 祁莉萍 吴红梅 肖文凯 段留法 |
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| 作者单位： | 解放军总医院老年心血管二科; |
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| 摘 要： | 目的横断面调查正常或轻度受损社区居民估测的肾小球滤过率(eGFR)及传统心血管危险因素与脉搏波速度(PWV)的关系。方法北京4个社区入选2285名18-96岁居民,平均年龄51±16岁,用问卷调查方法采集病史,自动示波测量仪检测PWV,同期化验血脂、肌酐、尿酸、血糖等指标,简化的MDRD公式估测肾小球滤过率(eGFR)。结果随着eGFR的下降,年龄、脉压、肌酐、餐后2h血糖、颈股PWV(cfPWV)均显著增高(P<0.001),但颈桡PWV(crPWV)组间比较无统计学意义(P=0.672)。整体人群中,cfPWV(r=-0.353,P<0.001)、颈踝PWV(caPWV,r=-0.167,P<0.001)与eGFR呈显著负相关,而crPWV与eGFR无相关关系(r=-0.033,P=0.115);经校正性别、年龄和收缩压后,仅cfPWV与eGFR呈微弱负相关(r=-0.047,P=0.026)。逐步回归显示,eGFR降低是女性cfPWV增高的独立危险因素(R2=0.495,P<0.001),而男性eGFR对cfPWV无显著影响。结论肾小球滤过率降低是女性肾功能正常或轻度减退人群动脉僵硬度增加的独立危险因素...
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| 关 键 词： | 动脉硬化 脉搏波速度 肾小球滤过率 横断面研究 |
Correlation between glomerular filtration rate and arteriosclerosis in community residents with normal or mildly impaired kidney function |
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| BIAN Su-yan,YE Ping,SHENG Li,LUO Lei-ming,XIAO Tie-hui,QI Li-ping,WU Hong-mei,XIAO Wen-kai,DUAN Liu-fa Second. Correlation between glomerular filtration rate and arteriosclerosis in community residents with normal or mildly impaired kidney function[J]. Piezoelectrics & Acoustooptics, 2010, 0(6) |
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| Authors: | BIAN Su-yan YE Ping SHENG Li LUO Lei-ming XIAO Tie-hui QI Li-ping WU Hong-mei XIAO Wen-kai DUAN Liu-fa Second |
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| Affiliation: | BIAN Su-yan,YE Ping,SHENG Li,LUO Lei-ming,XIAO Tie-hui,QI Li-ping,WU Hong-mei,XIAO Wen-kai,DUAN Liu-fa Second Department of Geriatric Cardiology,Chinese PLA General Hospital,Beijing 100853,China |
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| Abstract: | |
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| Keywords: | Arteriosclerosis Pulse Wave Velocity Glomerular Filtration Rate Cross-Sectional Studies |
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