Characterization of thermo-sensitive hydrogels based on poly(N-isopropylacrylamide)/hyaluronic acid |
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Authors: | Ramón Coronado Sara Pekerar Arnaldo T. Lorenzo Marcos A. Sabino |
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Affiliation: | 1.B5IDA Group, Department of Chemistry,Universidad Simón Bolívar,Caracas,Venezuela;2.IVIC, Venezuelan Institute of Scientific Research, Chemistry Center,Estado Miranda,Venezuela;3.USB Polymer Group, Department of Materials Science,Universidad Simón Bolívar,Caracas,Venezuela |
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Abstract: | In this study, an hydrogel was synthesized from the monomer N-isopropylacrylamide (NIPA), generating the poly(N-isopropylacrylamide) (PNIPA) and other formulations were synthesized in the presence of 1, 2, and 3% hyaluronic acid (HA) for obtain an interpenetrating polymer network. For all the obtained hydrogels, the thermo-sensitive response was studied since the lower critical solution temperature (LCST) and was analyzed by differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), and oscillatory rheology at constant frequency as a function of temperature. The LCST transition temperature (Tt onset) was found between 34.4 and 35.5 °C. By scanning electron microscopy (SEM) PNIPA-HA formulations showed a porous morphology. The applicability of the hydrogels as injectable and non-toxic materials was verified, respectively, by rheology results and by cytotoxicity studies through an in vitro test of cell hemolysis on blood agar. |
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