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| 4-乙酰氧基-2-氮杂环丁酮的合成 | |
| 引用本文： | 姚勃,曹晓燕,刘明星.4-乙酰氧基-2-氮杂环丁酮的合成[J].化学世界,2009,50(2). |
| 作者姓名： | 姚勃 曹晓燕 刘明星 |
| 作者单位： | 1. 武汉百科药物开发有限公司,湖北武汉,430056 2. 天茂实业集团股份有限公司,湖北天门,448000 3. 湖北工业大学生物工程学院,湖北武汉,430068 |
| 摘 要： | 设计了以醋酸乙烯酯和氯磺酰异氰酸酯为起始原料,经加成和消除反应,中间产物不需分离,直接制备了4-乙酰氧基-2-氮杂环丁酮,产物收率为66.6%。经质谱、核磁和红外等波谱鉴定了目标分子的结构。该法与文献相比,方法简单易行,成本低。 |
| 关 键 词： | 4-乙酰氧基-2-氮杂环丁酮 醋酸乙烯酯 氯磺酰异氰酸酯 合成 |
Synthesis of 4-Acetoxy-2-azetidinone |
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| YAO Bo,CAO Xiao-yan,LIU Ming-xing.Synthesis of 4-Acetoxy-2-azetidinone[J].Chemical World,2009,50(2). | |
| Authors: | YAO Bo CAO Xiao-yan LIU Ming-xing |
| Affiliation: | 1.Wuhan Biocause Pharmaceutical Development Co.;Ltd;Hubei Wuhan 430056;China;2.Hubei Biocause Pharmaceutical Co.;Hubei Tianmen 448000;3.Institute of Bioengineering;Hubei University of Technology;Hubei Wuhan 430068;China |
| Abstract: | 4-Acetoxy-2-azetidinone was synthesized by addition and elimination reactions from vinyl acetate and chlorosulfonyl isocyanate.The intermediate compound was not separated in this reaction process.The yield was 66.6%.The targeting compound was characterized by MS,()~1H NMR and IR.This method had the advantages of simple operation and cheap as compared with other methods in the literature. |
| Keywords: | 4-acetoxy-2-azetidinone vinyl acetate chlorosulfonyl isocyanate synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |