Preparation and physico-chemical characterisation of microporous polysaccharidic hydrogels |
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Authors: | Gemma Leone Rolando Barbucci Assunta Borzacchiello Luigi Ambrosio Paolo A Netti Claudio Migliaresi |
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Affiliation: | CRISMA and Department of Chemical and Biosystem Science and Technologies, University of Siena, Via Aldo Moro no 2, 53100 Siena, Italy. |
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Abstract: | A new technique to obtain microporous hydrogels was realised. It permits us to obtain a microporous structure directly on the already cross-linked hydrogel. It consists in stratifying the already cross-linked hydrogel on to a filter with known porosity and forcing the CO2 bubbles, derived from the addition of HCl to a porogen salt (NaHCO3), to cross through the filter first and then the matrix. By changing the porosity of the filter, it was possible to modulate the porous morphology of the hydrogels. The polysaccharides selected were hyaluronane, alginate, and carboxymethylcellulose. The influence of the porous morphology on the physico-chemical properties of the gel has been evaluated by FT-IR, FRAP, calorimetric, water uptake, and rheological analysis. |
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