Overview of preparation methods of polymeric and lipid-based (niosome,solid lipid,liposome) nanoparticles: A comprehensive review |
| |
Authors: | Ghasem Amoabediny Fateme Haghiralsadat Samira Naderinezhad Marco N. Helder Elham Akhoundi Kharanaghi Javad Mohammadnejad Arough |
| |
Affiliation: | 1. Department of Nano Biotechnology, Research Center for New Technologies in Life Science Engineering, University of Tehran, Tehran, Iran;2. Department of Biotechnology and Pharmaceutical Engineering, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran;3. Department of Life Science Engineering, Faculty of New Sciences &4. Technologies, University of Tehran, Tehran, Iran;5. Department of Nano Biotechnology, Research Center for New Technologies in Life Science Engineering, University of Tehran, Tehran, Iran;6. Department of Biotechnology and Pharmaceutical Engineering, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran;7. Department of Oral &8. Maxillofacial Surgery, VU University Medical Center, MOVE Research Institute Amsterdam;9. Department of Biotechnology, Faculty of Advanced Science and Technologies, University of Isfahan, Isfahan, Iran |
| |
Abstract: | A wide number of drug nanocarriers have emerged to improve medical therapies, and in particular to achieve controlled delivery of drugs, genes or gene expression-modifying compounds, or vaccine antigens to a specific target site. Of the nanocarriers, lipid-based and polymeric nanoparticles are the most widely used. Lipid-based systems like niosomes and liposomes are non-toxic self-assembly vesicles with an unilamellar or multilamellar structure, which can encapsulate hydrophobic/hydrophilic therapeutic agents. Polymeric nanoparticles, usually applied as micelles, are colloidal carriers composed of biodegradable polymers. Characteristics such as loading capacity, drug release rate, physical and chemical stability, and vesicle size are highly dependent on experimental conditions, and material and method choices at the time of preparation. To be able to develop effective methods for large scale production and to meet the regulatory requirements for eventual clinical implementation of nanocarriers, one needs to have in-depth knowledge of the principles of nanoparticle preparation. This review paper presents an overview of different preparation methods of polymeric and novel lipid-based (niosome and solid lipid) nanoparticles. |
| |
Keywords: | Drug delivery niosome polymeric nanoparticles preparation method solid lipid nanoparticles |
|
|