Carboplatin liposomal nanoparticles: Preparation,characterization, and cytotoxicity effects on lung cancer in vitro environment |
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| Authors: | Donya Poy Hasan Ebrahimi Shahemabadi Hemen Moradi-Sardareh |
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| Affiliation: | 1. Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran;2. Department of Microbiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran;3. Department of Biochemistry, Tehran University of Medical Science, Tehran, Iran |
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| Abstract: | The study aimed to encapsulate anticancer drug carboplatin into liposomal nanoparticles by reverse-phase evaporation technique and evaluate its efficacy on lung cancer in vitro environment. Nanoparticles were characterized in terms of size, drug loading efficiency, drug retention capability, and cytotoxicity effects. Nanoscale particles with 67% drug encapsulation efficiency were prepared. Also, high retention capability (drug release equal to 25% after 72?h) of the nanodrug was confirmed. In addition, results of the nanodrug cytotoxicity indicated nanoparticles increased potency of the drug by approximately 90%. Findings of the study indicated liposome can be used for carboplatin delivery to lung cancer. |
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| Keywords: | Carboplatin liposome lung cancer nanotechnology reverse-phase evaporation TC1 |
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