Controlled release of fluorouracil (5-FU) from chitosan-co-poly(ethylene glycol)/ poly(glycerol sebacate)-co-poly(ethylene glycol)-coated iron oxide |
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| Authors: | Shayan Naghizadeh Nahid Hassanzadeh Nemati Alireza Hassani Najafabadi Hassan Niknejad |
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| Affiliation: | 1. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran;2. Department of Pharmaceutical Sciences and the Bio Interfaces Institute, University of Michigan, Ann Arbor, Michigan, USA;3. Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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| Abstract: | A blend of polyglycerol sebacate-poly ethylene glygol/chitosan-poly ethylene glycol-coated iron oxide (PGS-PEG/CS-PEG@Fe3O4) nanoparticles for 5FU delivery was prepared by reverse ultrasonic emulsification method. To enhance polymers’ solubility, PEG was grafted. Chemical characterization was performed through Fourier transformed infrared and proton nuclear magnetic resonance spectra. In vitro assay revealed that release profile of 5FU-loaded PGS-PEG/CS-PEG@Fe3O4 is sustained. Moreover, cytotoxicity was analyzed on HT29 cell line at the presence of external magnetic field using the lactate dehydrogenase and Alamar Blue. Results illustrate that (PGS-PEG/CS-PEG@Fe3O4) is promising to use as a carrier for 5FU anticancer agent with sustained tailored release. |
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| Keywords: | 5-FU Chitosan drug delivery nanoparticles poly(ethylene glycol) poly(glycerol sebacate) |
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