Poly(lactic-co-glycolic acid): The most ardent and flexible candidate in biomedicine! |
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| Authors: | Amir Roointan Sedigheh Kianpour Fatemeh Memari Molood Gandomani Seyed Mohammad Gheibi Hayat |
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| Affiliation: | 1. Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran;2. Department of Pharmaceutical Biotechnology, Pharmaceutical Sciences Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran;3. Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;4. Department of Bioengineering, Biotechnology Research Center, Cyprus international University, Nicosia, Cyprus;5. Student Research Committee, Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran |
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| Abstract: | Among all polymers, without doubt, poly(lactic-co-glycolic acid) (PLGA) is the most popular one in biology and biomedicine fields. Having a tunable structure, a controllable and desired release profile, huge capacity of functionalization with various agents besides an incredible biosafety and biocompatibility, which led to its food and drug administration (FDA) approval, is among some outstanding features of this polymer. Cancer treatment using PLGA-based vehicles carrying anticancer agents, delivery of various active compounds from drugs to peptides and vaccines, tissue regeneration, and treatment of central nervous system disorders, all shows the potential of this polymer in this area. Nowadays, the focus of most investigations is on designing the most efficient PLGA formulation and improving its effectiveness with various synthesis and postsynthesis modifications. The aim of this review is to mention some recent investigations directed to improve PLGA efficiency in biomedical area. |
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| Keywords: | Cancer therapy drug delivery nanoparticles poly(lactic-co-glycolic acid) targeting |
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