Response to Zenz and Altiner

Ordered mixes were produced using a fructose-based excipient as a coarse carrier component and fine-particle pyridoxine hydrochloride (vitamin B₆) as the adherent component. Prior to mixing, the fructose agglomerates were conditioned for 48 h at either 0% RH or 55% RH at 20 °C. Under these conditions, one lot of fructose had a moisture content of 0.24 wt.% and the other lot had a moisture content of 0.74 wt.%. Following mixing, the powders were subjected to vibration at various frequencies in the range 25 to 200 Hz and accelerations in the range 9.81 to 39.24 m/s². It was found that whilst ordered mixes produced using fructose at 0.24 wt.% moisture content were unstable, those produced using 0.74 wt.% moisture content fructose were extremely stable and segregation resistant.The formation of ordered units with increased adhesion in carriers with higher moisture content suggested that these ordered mixes could be considered as spontaneous granulations.