| 1-苄基-4-哌啶酮的合成研究 |
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| 引用本文： | 蒋忠良,王书玉,段辉.1-苄基-4-哌啶酮的合成研究[J].化学世界,2004,45(9):484-486. |
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| 作者姓名： | 蒋忠良 王书玉 段辉 |
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| 作者单位： | 同济大学化学系,上海,200092 |
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| 摘 要： | 以苄胺和丙烯酸甲酯为原料,依次经过加成、狄克曼缩合及水解脱羧反应,简捷、高效地合成了1-苄基-4-哌啶酮。分别对原料配比、合成过程等方面进行了改进,同现有文献相比,不仅总产率由原来的65%提高到75.3%,而且还简化了合成工艺,节省了原料和成本,更适合于大规模生产。元素分析、红外光谱、核磁氢谱分析结果表明,产物具有很高的纯度。
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| 关 键 词： | 1-苄基-4-哌啶酮 哌啶衍生物 Dieckmann缩合 合成改进 |
| 文章编号： | 0367-6358(2004)09-0484-03 |
Study on the Synthesis of 1-Benzyl-4-piperidone |
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| JIANG Zhong-liang,WANG Shu-yu,DUAN Hui.Study on the Synthesis of 1-Benzyl-4-piperidone[J].Chemical World,2004,45(9):484-486. |
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| Authors: | JIANG Zhong-liang WANG Shu-yu DUAN Hui |
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| Abstract: | 1-Benzyl-4-piperidone was synthesized with benzylamine and methyl acrylate as raw materials via a series of 1,4-addition, Dieckmann condensation and hydrolysis decarboxylafion reactions. The proportion of materials and the synthetic condition were optimized. The total yield was increased from 65% to 75.3%. The product was characterized by elemental analysis, IR and ()~1H NMR. |
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| Keywords: | 1-benzyl-4-piperidone piperidine derivatives Dieckmann condensation improvement on synthesis |
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