SISO-based hot-melt pressure-sensitive adhesives for transdermal delivery of hydrophilic drugs |
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| Affiliation: | 1. School of Chemical Engineering, Dalian University of Technology, No.2 Linggong Road, Ganjingzi District, Dalian City 116024, China;2. School of Pharmaceutical Science and Technology, Dalian University of Technology, No.2 Linggong Road, Ganjingzi District, Dalian City 116024, China;3. State Key Laboratory of Fine Chemicals, Dalian University of Technology, No.2 Linggong Road, Ganjingzi District, Dalian City 116024, China;1. ETI Converting, 1490H Rue Nobel, Boucherville, Montreal, QC, Canada J4B 5H3;2. National Research Center, Polymers Department, Tahrir St., Dokki, Cairo, Egypt;1. Department of Chemical Engineering, Bucknell University, Lewisburg, PA, 17837, USA;2. X-Ray Science Division, Argonne National Laboratory, Lemont, IL, 60439, USA;1. Advanced and Applied Research Institute, Nichiban Co., Ltd., Nihongi-Shinmachi, Anjo, Aichi 446-8531, Japan;2. Photon Factory, High Energy Accelerator Research Organization, Tsukuba, Ibaraki 305-0801, Japan;3. Department of Biobased Materials Science, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan;1. College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA;2. College of Pharmacy, Jazan University, Gizan, Saudi Arabia;3. School of Pharmacy, Texas Tech University Health Sciences Center, Dallas, TX, USA |
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| Abstract: | A monomer-activated anionic polymerization approach was utilized to synthesize poly(styrene-b-isoprene-b-styrene-b-ethylene oxide) tetrablock terpolymers (SISO), which were melt-mixed with tackifiers and plasticizer to develop polar SISO-based hot-melt pressure-sensitive adhesives (HMPSAs) for transdermal delivery of hydrophilic drugs. Their hydrophilic performance was characterized using contact angle analysis. Their adhesive performances were measured in terms of 180° peel strength and holding power. In vitro drug release experiments were carried out using a modified Franz type horizontal diffusion cell, in which geniposide was chosen as a hydrophilic model drug. The results show that poly(ethylene oxide) (PEG) blocks exhibit substantial effects on adhesive performance and the release behavior of the model drug. The shorter PEG molecular chains enhance adhesive performance and the cumulative release rate of the model drug in the SISO-based HMPSAs. The longer PEG molecular chains tend to crystallize. Their crystallization structures have negative effects on adhesive performance and limit the dissolution and diffusion of drugs in the SISO-based HMPSAs. Therefore, appropriate PEG molecular chains are required to fabricate SISO-based HMPSAs with excellent adhesive performance for transdermal delivery of hydrophilic drugs. |
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| Keywords: | Hot-melt pressure-sensitive adhesives SISO copolymers In vitro drug release Adhesive performance |
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