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| 代谢工程技术及其在微生物育种的应用 | |
| 引用本文： | 张红岩,辛雪娟,申乃坤,莫永生,孙文波.代谢工程技术及其在微生物育种的应用[J].酿酒,2012,39(4):17-21. |
| 作者姓名： | 张红岩 辛雪娟 申乃坤 莫永生 孙文波 |
| 作者单位： | 1. 广西科学院生物研究所,广西南宁,530003 2. 潍坊市第一中学,山东潍坊,261000 3. 广西科学院非粮生物质酶解国家重点实验室,广西南宁,530007 |
| 基金项目： | 国家自然科学基金地区科学基金项目(31160023).广西区科学研究与技术开发课题(桂科攻11107008-4).广西科学院基金 |
| 摘 要： | 代谢工程(Metabolic Engineering),亦称途径工程(Pathway Engineering),是一门利用分子生物学原理系统地分析细胞代谢网络,并通过DNA重组技术合理设计细胞代谢途径及遗传修饰,进而完成细胞特性改造的应用性学科。代谢工程综合了生物化学、化学工程、数学分析等多学科内容,是当前国内外学者研究热点之一。论述了代谢工程的发展过程、基本原理及特点以及该项技术在微生物育种的最新应用进展,并展望了未来发展前景。 |
| 关 键 词： | 代谢工程 代谢网络 代谢流分析 代谢控制分析 |
Metabolic Engineering Technology and Its Applications in Microbial |
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| Breeding ZHANG Hong-yan,XIN Xue-juan,SHEN Nai-kun,MO Yong-sheng,SUN Wen-bo.Metabolic Engineering Technology and Its Applications in Microbial[J].Liquor Making,2012,39(4):17-21. | |
| Authors: | Breeding ZHANG Hong-yan XIN Xue-juan SHEN Nai-kun MO Yong-sheng SUN Wen-bo |
| Affiliation: | 1.Biology Institute, Guangxi Academy of Sciences, Nanning 530003, China; 2. Weifang No.1 Middle school, Shandong province, Weifang 261000, China; |
| Abstract: | Metabolic Engineering, also named Pathway Engineering, is a applied subject utilizing molecular biology principle to systematically analysis cell metabolic network and using recombinant DNA technology to design reasonably cell metabolic pathway and genetic modification, further completing the reconstruction of cell characters. Metabolic engineering exploit biochemistry, chemical engineering and mathematical analysis, so it offers researchers of different field new contents, at the same time becomes a hotspot presently. This review summarizes about the elementary theories of metabolic engineering including the produce and principle, the applications in microbial breeding, as well as the recent developments and new trends. |
| Keywords: | metabolic engineering metabolic network metabolic fluxes analysis metabolic control analysis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |