Anticancer and Antioxidant Activities in Ganoderma lucidum Wild Mushrooms in Poland,as Well as Their Phenolic and Triterpenoid Compounds |
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| Authors: | Joanna Kolniak-Ostek Jan Oszmia&#x;ski Anna Szyjka Helena Moreira Ewa Barg |
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| Affiliation: | 1.Department of Fruit, Vegetable and Plant Nutraceutical Technology, Wrocław University of Environmental and Life Sciences, 37 Chełmońskiego Street, 51-630 Wroclaw, Poland;2.Department of Basic Medical Sciences, Faculty of Pharmacy, Wroclaw Medical University, 211 Borowska Street, 50-556 Wrocław, Poland |
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| Abstract: | The goal of this study was to the assess anti-cancer and antioxidant properties of the Ganoderma lucidum fruiting body, and to identify bioactive compounds found in their extracts. Significant antiproliferative activity was observed against MCF-7, MCF-7/DX, LOVO, LOVO/DX, MDA-MB 231, SW 620, and NHDF cell lines. With IC50 values of 25.38 µg/mL and 47.90 µg/mL, respectively, the extract was most effective against MDA-MB 231 and SW 620 cell lines. The bioactive compounds were identified using an ACQUITY UPLC-PDA-MS system. The extracts contained 13 triterpenoids and 28 polyphenols from the flavonols, phenolic acids, flavones, flavan-3-ols, and stilbenes families. Ganoderic acid derivative was found to be the most abundant triterpenoid (162.4 mg/g DW), followed by ganoderic acid B (145.6 mg/g DW). Resveratrol was the most abundant phenolic in the extract (5155.7 mg/100 g DM). The findings could explain why G. lucidum extracts are used in folk medicine. |
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| Keywords: | lingzhi reishi mushrooms antioxidants bioactive compounds LC-MS |
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