Effects of Oral Administration of Chitin Nanofiber on Plasma Metabolites and Gut Microorganisms |
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| Authors: | Kazuo Azuma Ryotaro Izumi Mari Kawata Tomone Nagae Tomohiro Osaki Yusuke Murahata Takeshi Tsuka Tomohiro Imagawa Norihiko Ito Yoshiharu Okamoto Minoru Morimoto Hironori Izawa Hiroyuki Saimoto Shinsuke Ifuku |
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| Affiliation: | 1.Department of Clinical Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8533, Japan; E-Mails: (T.O.); (Y.M.); (T.T.); (T.I.); (N.I.); (Y.O.);2.Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan; E-Mails: (R.I.); (M.K.); (T.N.); (H.I.); (H.S.);3.Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University, Tottori 680-8550, Japan; E-Mail: |
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| Abstract: | The aim of this study was to examine the effects of oral administration of chitin nanofibers (CNFs) and surface-deacetylated (SDA) CNFs on plasma metabolites using metabolome analysis. Furthermore, we determined the changes in gut microbiota and fecal organic acid concentrations following oral administrations of CNFs and SDACNFs. Healthy female mice (six-week-old) were fed a normal diet and administered tap water with 0.1% (v/v) CNFs or SDACNFs for 28 days. Oral administration of CNFs increased plasma levels of adenosine triphosphate (ATP), adenosine diphosphate (ADP), and serotonin (5-hydroxytryptamine, 5-HT). Oral administration of SDACNFs affected the metabolisms of acyl-carnitines and fatty acids. The fecal organic level analysis indicated that oral administration of CNFs stimulated and activated the functions of microbiota. These results indicate that oral administration of CNFs increases plasma levels of ATP and 5-HT via activation of gut microbiota. |
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| Keywords: | chitin nanofibers surface-deacetylated chitin nanofibers metabolome analysis ATP serotonin acyl-carnitine fatty acids |
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