| 硝基咪唑N-羟烷基化的研究 |
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| 引用本文： | 李小松,陈义朗,余扬帆,邓瑞红. 硝基咪唑N-羟烷基化的研究[J]. 化学世界, 2002, 43(8): 419-421 |
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| 作者姓名： | 李小松 陈义朗 余扬帆 邓瑞红 |
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| 作者单位： | 1. 南昌大学化学系,江西,南昌,330047
2. 南昌大学生物系,江西,南昌,330047 |
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| 摘 要： | N-羟烷基化反应是制备塞克硝唑 ,奥硝唑等硝基咪唑类药物的关键步骤。通过对此过程的不同方法进行了对比 ,提出一条以环硫酸酯为 N-羟基化试剂 ,并以塞克硝唑为例进行了合成。此路线产率较高 ,操作方便 ,易于工业化生产。
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| 关 键 词： | N-羟烷基化反应 硝基咪唑 合成 |
| 文章编号： | 0367-6358(2002)08-0419-03 |
Study on N-hydroxylalkylation of Nitro-imidazoles |
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| Abstract: | N hydroxylalkylation of nitro imidazoles is a key procedure in preparing medicines such as secnidazole and ornidazole. By comparison of different approaches, a synthesis route was given, in which cyclic sulfate was used as N hydroxylalkylation reagent. Secnidazole was synthesized by this route as an example, and a relatively satisfying yield was achieved. |
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| Keywords: | N hydroxylalkylation nitro imidazoles synthesis |
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