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Core-shell structured nanoassemblies based on β-cyclodextrin containing block copolymer and poly(β-benzyl L-aspartate) via host-guest complexation |
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| Authors: | Zhang Jianxiang Ma Peter X |
| Affiliation: | a Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA b Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, China c Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA d Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA e Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA |
| Abstract: | Double hydrophilic copolymers (PEG-b-PCDs) with one PEG block and another block containing β-cyclodextrin (β-CD) units were synthesized by macromolecular substitution reaction. Via a dialysis procedure, complex assemblies with a core-shell structure were prepared using PEG-b-PCDs in the presence of a hydrophobic homopolymer poly(β-benzyl l-aspartate) (PBLA). The hydrophobic PBLA resided preferably in the cores of assemblies, while the extending PEG chains acted as the outer shell. Host-guest interaction between β-CD and hydrophobic benzyl group was found to mediate the formation of the assemblies, where PEG-b-PCD and PBLA served as the host and guest macromolecules, respectively. The particle size of the assemblies could be modulated by the composition of the host PEG-b-PCD copolymer. The molecular weight of the guest polymer also had a significant effect on the size of the assemblies. The assemblies prepared from the host and guest polymer pair were stable during a long-term storage. These assemblies could also be successfully reconstituted after freeze-drying. The assemblies may therefore be used as novel nanocarriers for the delivery of hydrophobic drugs. |
| Keywords: | Host-guest interactions Self-assembly β-cyclodextrin |
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