Surface modifications of polypropylene membranes used for blood filtration |
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Authors: | Estelle Gé rard,Claudio Salvagnini,Maryam Momtaz,Pascal Marmey,Jacqueline Marchand-Brynaert |
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Affiliation: | a Université Catholique de Louvain, Institut de la Matière Condensée et des Nanosciences, Bâtiment Lavoisier, place L. Pasteur n°1, B-1348 Louvain-la-Neuve, Belgium b MacoProductions, Chaussée Fernand Forest n°200, F-59200 Tourcoing, France |
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Abstract: | The surface of two commercial meltblown polypropylene (PP) membranes, used for the filtration of blood products, were modified by wet chemistry treatments (carbodiimide, tosyl chloride and trihalogeno-triazines) in the case of the oxygen-plasma treated membrane (O2-PP), and by photochemistry using molecular clips in the case of the native PP membrane. The most efficient technique uses trifluoro-triazine reagent for the activation of both hydroxyl- and carboxyl-functions of O2-PP. It enables the fixation of amine-terminated molecules with high degrees of derivatization (∼700 pmol/cm2), without inducing modification of the membrane morphology nor cytotoxicity. Only a weak decrease of surface hydrophilicity was measured after the treatments and steam-sterilization. This method was applied for the grafting of peptides (Gly-Gly-Gly-Gly-Gly, Gly-Arg-Gly-Asp-Ser, home-made modified Leu-Asp-Val) on O2-PP membranes incorporated into multi-layer filter devices. These modified filters showed improved properties of leukocyte depletion in blood filtration experiments, principally due to the wetting properties of the membranes. |
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Keywords: | Polypropylene membrane Surface chemistry Blood filtration |
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