Solubility analysis of clozapine and lamotrigine in supercritical carbon dioxide using static system |
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Authors: | Majid Haji Hosseini Ali Reza Khanchi |
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Affiliation: | a Department of Chemistry, Faculty of Basic Science, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran b Nuclear Fuel Cycle Research School, Nuclear Science & Technology Research, Atomic Energy Organization of Iran, Tehran, Iran |
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Abstract: | The experimental techniques used to obtain the solubilities of clozapine and lamotrigine in supercritical carbon dioxide include a simple static technique. The solubility measurements were performed at temperatures between 318 and 348 K and pressures between 121.6 and 354.0 bar. These chemicals have solubilities with values ranging from 3.6 × 10−6 to 4.2 × 10−5 (clozapine) and 1 × 10−6 to 6 × 10−5 (lamotrigine) mole fraction. The solubility data were correlated using four semi-empirical density-based models (Chrastil, Bartle, K-J and M-T models). Correlation of the results shows good self-consistency of the data obtained with the Bartle model for clozapine with an overall average absolute relative deviation (AARD%) of 11.21. The calculated results with each four models show satisfactory agreement with the experimental data for lamotrigine with an overall AARD% 11.72, 8.99, 2.75, 3.86 for Chrastil, K-J, Bartle, M-T models, respectively. Using the correlation results, the heat of drug-CO2 solvation and that of drug vaporization were approximated. |
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Keywords: | Clozapine Lamotrigine Drug Solubility Supercritical carbon dioxide |
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