Adsorptive crystallization of benzoic acid in aerogels from supercritical solutions |
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Authors: | BSK Gorle W Arlt |
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Affiliation: | a Separation Science and Technology, Friedrich - Alexander Universität Erlangen - Nürnberg, Egerlandstr. 3, 91058 Erlangen, Germany b Separation Science and Thermal Separation Technology, Technical University of Hamburg, Eissendorfer Str. 38, 21073 Harburg, Germany |
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Abstract: | In this work, adsorption and crystallization of benzoic acid in different porous carriers (silica aerogel, MCM41, Trisopor glass, zeolite) from supercritical CO2 solutions is studied. The main purpose is to reveal the influence of the adsorptive properties of the carrier on the crystallization behavior of the solute. Therefore, both adsorption and crystallization processes are studied as a function of carrier's surface properties. Adsorption of the solute and CO2 is measured in situ using a magnetic suspension balance, whereas crystallization is realized in a high pressure view cell. The carriers could be loaded with up to ∼35 wt.% of benzoic acid, depending on the nature and the amount of the functional groups of the carrier. The size of the benzoic acid particles obtained inside the aerogel matrix depends on the crystallization conditions and is in the range of ∼20 nm-50 μm. The crystallinity of the particles was studied and it is shown that the physical state of the loaded benzoic acid inside the pores of aerogels is influenced by benzoic acid-aerogel surface interactions: strong interactions favor the amorphous form, weak interactions favor crystalline particles. The amorphous form of benzoic acid is shown to be stable over a long time period. Thus, silica aerogels can be used for stabilizing amorphous forms of organic compounds, which can be used for instance in pharmaceutical applications for the improvement of drug bioavailability. |
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Keywords: | BET Brunauer Emmett and Teller -CH3 -Methyl CHN carbon hydrogen and nitrogen m(p T)absolute mass of solute/solvent adsorbed (g)/aerogel (g) m(p T)excess mass of solute/solvent adsorbed (g)/aerogel (g) OR alkyl group SLG solid liquid gas SANS small angle neutron scattering Tm melting temperature VOC's volatile organic compounds Vb volume of basket Vs volume of sample (aerogel) Vads volume of adsorbed CO2 ρb bulk density of CO2 or CO2+ benzoic acid ρadsorbed density of adsorbed CO2 Δm weight difference due to adsorbed solute/solvent |
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