| 奥氮平合成工艺的研究 |
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| 引用本文： | 高敏,张宇驰,卢苗苗,江炯,陈万胜,荆丹,朱海峰. 奥氮平合成工艺的研究[J]. 化工时刊, 2011, 25(9): 28-30. DOI: 10.3969/j.issn.1002-154X.2011.09.010 |
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| 作者姓名： | 高敏 张宇驰 卢苗苗 江炯 陈万胜 荆丹 朱海峰 |
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| 作者单位： | 连云港职业技术学院医化学院,江苏 连云港,222005 |
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| 基金项目： | 2010年江苏省高等学校大学生实践创新训练计划项目 |
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| 摘 要： | 以硫、丙醛以及丙二腈为原料,经过关环、缩合和还原合成奥氮平；通过改变反应物的配料比、控制反应温度等方法缩短反应时间,优化工艺路线,并提高奥氮平的收率,总收率达到40％.
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| 关 键 词： | N-甲基哌嗪 奥氮平 合成 优化工艺 |
Study on the Synthesis Procsee of Olanzapine |
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| Gao Min,Zhang Yuchi,Lu Miaomiao,Jiang Jiong,Chen Wansheng,Jing Dan,Zhu Haifeng. Study on the Synthesis Procsee of Olanzapine[J]. Chemical Industry Times, 2011, 25(9): 28-30. DOI: 10.3969/j.issn.1002-154X.2011.09.010 |
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| Authors: | Gao Min Zhang Yuchi Lu Miaomiao Jiang Jiong Chen Wansheng Jing Dan Zhu Haifeng |
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| Affiliation: | Gao Min Zhang Yuchi Lu Miaomiao Jiang Jiong Chen Wansheng Jing Dan Zhu Haifeng(Medical college,Liangyungang Technical College,Jiangsu Lianyungang 222006) |
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| Abstract: | Olanzapine was synthesized from sulphur,propioaldehyde and malononitrile by ring-closure,reduction,condensation reactions;The process route was optimized by changing the reactant ratio of ingredients,reaction temperature and other methods to shorten the reaction time,and increase the yield of olanzapine.The total yield was up to 40%. |
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| Keywords: | N-methyl piperazine olanzapine synthesis Optimization of process |
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