Gelatin-Acacia Complex Coacervation as a Method for Ketoprofen Microencapsulation

Abstract

Ketoprofen microcapsules were prepared by complex coacervation between gelatin and acacia, and dried with different methods: isopropanol addition, spray-drying, and freeze-drying, Successively, microparticles were analyzed by infrared thembalance, ultraviolet spectroscopy, optical and scanning electron microscopy, and sieves; and subjected to dissolution studies in order to examine parameters such as yield, moisture content, encapsulation percentage, morphology of solid particles, particle size, and dissolution behavior. Provided that encapsulation and drying methods did not affect ketoprofen dissolution profiles, the most appropriate drying method for industrial purposes was spray-drying.