Aging Effect on Stability and Eioavailability of Glibenclamide in Solid Dosage,Forms

Abstract

Asing effect of some solid dosage form of glibenclamide, after storage at various storage conditions and accelerated temperatures for certain length of time, affected percentage degradation, physical. properties, in-vitro dissclution and in- vivo performances, has been, investigated and compared with the marketed tablets of Dionil®. The percentage degradation responding to accelerated conditions has been extrapolated by formal Arrhenius treatment. Fowever, maximum stability and highest shelf-life of direct compression, lactose tablets, followed by Dionll^R and then suppositories have been observed. The aging and elevation of temperature, adversely affected dissolution rate and indicated a decrease In bioavailability of glibenclamide based on C_max, and T_max and AUC.