Differential Scanning Calorimetry of Aspartame-Mannitol Mixture

Abstract

Differential scanning calorimetry was used to study both the qualitative and quantitative thermal properties of mixtures of aspartame with both mannitol and granular mannitol. Aspartame was found to be compatible with both forms of mannitol. No aspartame decomposition was observed in the preparation of a fused aspartame-mannitol mixture prepared at 161-165°C. L-(-)-leucine can be recommended as soluble lubricant for formulations containing aspartame and mannitol.