Accelerated Tests in Relation to Shelf-Life of Multivitamin Liquid Preparations

Abstract

Chemical kinetics for the decomposition of vitamin A, vitamin B₁, sodium pantothenate, folic acid and vitamin B₁₂ were studied at higher temperatures in the case of two multi-vitamin preparations. Vitamin A, vitamin B₁ and sodium pantothenate were found to decompose in accordance with the first order reaction at higher temperatures, whereas folic acid and vitamin B₁₂ did not follow first order kinetics. It was concluded that, in the cases of multivitamin preparations, accelerated study at higher temperatures was feasible only in the case of vitamin A, vitamin B₁ and sodium pantothenate.