Evaluation of the Usefulness of Cloud Point Elevation to Predict Transdermal Delivery Enhancers

Abstract

The use of cloud point temperature elevation to predict transdermal delivery enhancers was evaluated by conducting cloud point experiments on penetration enhancers of known ability. The ability of a compound to elevate the cloud point temperature could not be related to penetration enhancement neither in ranking nor magnitude. After comparison of the molecular interactions that cause cloud point elevation and transdermal delivery enhancement, no correlation between these two mechanisms could be established.