In-Vitro Evaluation of Antacid Suspension |
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Abstract: | AbstractThree conceptually different titration procedures are used to evaluate the performance of several antacid suspension products: RIOPAN, RIOPAN PLUS, MAALOX, MAALOX PLUS, AND MYLANTA. When the static acid neutralization capacity test is performed, both RIOPAN and RIOPAN PLUS possess more acid neutralizing capacity, on an equal weight basis, than MAALOX, MAALOX PLUS or MYLANTA. The results of a pH-stat titration test show the RIOPAN products react 10 times faster with acid than other produced based on time to half-neutralization. The dynamic acid neutralizing capacity test (modified Beekman procedure) shows onset of action at pH 3 for the RIOPAN product to be 20 times faster than for MAALOX PLUS and 56 times faster than for MYIANTA. Duration of acid neutralization at pH above 3 for the RIOPAN products is two times longer than for MAALOX or MAALOX PLUS and 1.6 times longer than for MYIANTA. |
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