Medicament Release from Suppository Bases: III. Ibuprofen - Physicochemical Characteristics and Bioavailability in Rabbits

Abstract

This investigation was designed to determine the invitro release of ibuprofen from suppository bases, and their invivo bioavailability in rabbits. Suppositories containing ibuprofen were made by the fusion method with Theobroma oil, Witepsol H-15 and PEG 1540. In order to produce an exact dosage form, the displacement value was determined. The suppository hardness was determined by utilizing the SBT (Erweka) apparatus and it was found that the Witepsol H-15 allows the formation of brittler suppositories. The release rates were determined with the USP dissolution apparatus and with cellophane membrane and it was found to be: PEG 1540 > Witepsol H-15 > Theobroma oil. The bioavail-ability of Indomethacin after rectal administration was: PEG 1540 > Witepsol H-15 > Theobroma oil which correlates with the invitro release.