Michoencapsulation and in Vitro Dissolution of Oxazepam from Ethyl Cellulose Microcapsules

Abstract

Microcapsules of oxazepam with core:wall ratios 1:1 and 1:2 have been prepared by coacervation-phase separation method, using ethyl cellulose as a coating material. Phase separation was obtained by adding a salt solution to the dispersion of a water insoluble material in organic solution. Mioroencapsulation process protected oxazepam from photochemical decomposition and retarded its release. Release of the drug into simulated gastric and intestinal juice was studied. In vitro dissolution studies showed that first order release characteristics were exhibited.