癌症“细菌疗法”的研究进展

目前的癌症治疗方法毒性大,定位性差且不能有效穿透癌细胞,因此治疗效果有限。基因工程细菌能够准确的定位于所有肿瘤区域而克服这些缺点,其转运机理包括特殊的趋化性,优先生长和厌氧生长。目前的研究进展包括细胞毒素释放的时序控制,前体药物的酶激活和生理活性物质的分泌。经基因改造的细菌可表达肿瘤坏死因子-α,缺氧诱导因子-1-α,抗体,白细胞介素-2和胞嘧啶脱氨酶等,这些代谢产物具有增强肿瘤治疗效果的作用。本文对癌症＂细菌疗法＂的相关研究进行综述。

Progress of Bacterial Therapies in Cancer Treatment

Current cancer therapies have limited efficacy because they are highly toxic,ineffectively target tumors,and poorly penetrate tumor tissue.Engineered bacteria have potential to overcome these limitations by actively targeting all tumor regions.Examples of transport mechanisms include specific chemotaxis,preferred growth,and hypoxic germination.Recent advances include temporal control of cytotoxin release,enzymatic activation of pro-drugs,and secretion of physiologically active biomolecules.Bacteria have bee...