| 2-甲基-5-羟乙基氨基苯酚的合成工艺研究 |
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| 引用本文： | 叶茂溥,杨春恬,高鋆.2-甲基-5-羟乙基氨基苯酚的合成工艺研究[J].精细化工中间体,2011,41(6):44-47. |
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| 作者姓名： | 叶茂溥 杨春恬 高鋆 |
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| 作者单位： | 温州市工业科学研究院,浙江温州,325028 |
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| 基金项目： | 浙江省科技计划(2009C21015)资助项目 |
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| 摘 要： | 以5-氨基-2-甲基苯酚为起始原料,采用氯甲酸氯乙酯作为羟乙基化试剂,经羟乙基化、环化、水解反应合成目标化合物2-甲基-5-(N-羟乙基)氨基苯酚。产品结构经过红外光谱、核磁共振氢谱、质谱分析验证。该方法反应选择性高、收率高、易分离提纯、易操作。
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| 关 键 词： | 2-甲基-5-(N-羟乙基)氨基苯酚 5-氨基-2-甲基苯酚 羟乙基化 |
Study on the Synthesis of 2-Methyl-5-hydroxyethylaminophenol |
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| YE Mao-pu
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YANG Chun-tian
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GAO Yun.Study on the Synthesis of 2-Methyl-5-hydroxyethylaminophenol[J].Fine Chemical Intermediates,2011,41(6):44-47. |
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| Authors: | YE Mao-pu YANG Chun-tian GAO Yun |
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| Affiliation: | (Wenzhou Institute of Industry & Science,Wenzhou 325028,China) |
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| Abstract: | 5-Amino-2-methylphenol was hydroxyethylated with chloroethyl chloroformate,followed by cyclization and hydrolysis to give the title compound.The product was confirmed with 1H NMR,IR and MS spectra.This method has the advantages of high yield and selectivity,less by-products and easy operation. |
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| Keywords: | 2-methyl-5-hydroxyethylaminophenol hydroxyethylation |
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