| 乙酰苯胺合成新方法 |
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| 引用本文： | 伊茂聪,毛武涛,王建辉.乙酰苯胺合成新方法[J].化学与生物工程,2011,28(12):56-58. |
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| 作者姓名： | 伊茂聪 毛武涛 王建辉 |
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| 作者单位： | 天津大学理学院,天津,300072 |
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| 摘 要： | 报道了以N,N-二甲基乙酰胺(DMAc)为乙酰化试剂,苯胺在氯化铵的作用下合成乙酰苯胺的新方法.研究了反应温度和原料配比等因素对乙酰苯胺产率的影响,确定最佳反应条件为:N,N-二甲基乙酰胺为乙酰化试剂和溶剂,n(氯化铵):n(苯胺)=2:1、反应温度166℃、回流反应时间3h,此条件下乙酰苯胺产率达到98.0％.与常规...
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| 关 键 词： | 乙酰苯胺 N N-二甲基乙酰胺 氯化铵 苯胺 |
A Novel Synthesis Process of Acetanilide |
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| YI Mao-cong
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MAO Wu-tao
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WANG Jian-hui.A Novel Synthesis Process of Acetanilide[J].Chemistry & Bioengineering,2011,28(12):56-58. |
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| Authors: | YI Mao-cong MAO Wu-tao WANG Jian-hui |
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| Affiliation: | (School of Science,Tianjin University,Tianjin 300072,China) |
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| Abstract: | In this paper,acetanilide was synthesized from phenylamine and ammonium chloride with N,N-dimethylacetamide(DMAc) as acylation agent.The effects of reaction temperature and reactant ratio on the yield were investigated.And the optimum reaction conditions were obtained as follows:the molar ratio of ammonium chloride to phenylamine was 2∶1,the reaction temperature was 166 ℃,the refluxing reaction time was 3 h.Under above reaction conditions,the yield reached 98.0%.Compared with the traditional preparation methods of acetanilide,this method was simple in operation and after-treatment with high yield,so it was more suitable for industrial production. |
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| Keywords: | acetanilide N N-dimethylacetamide(DMAc) ammonium chloride phenylamine |
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