| 盐酸替罗非班的合成研究 |
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| 引用本文： | 刘超,陆旭芳,耿元硕,李志裕.盐酸替罗非班的合成研究[J].精细化工中间体,2013(2):42-45,65. |
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| 作者姓名： | 刘超 陆旭芳 耿元硕 李志裕 |
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| 作者单位： | 中国药科大学药物化学教研室 |
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| 摘 要： | 以4-(4-哌啶基)-1-氯丁烷、L-酪氨酸等为原料经过7步反应得到盐酸替罗非班。此合成路线操作简易,总收率达21.6%,中间体及最终产物结构均经过MS和1H NMR确证。
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| 关 键 词： | 血小板GPIIb/IIIa受体拮抗剂 盐酸替罗非班 合成 |
Synthesis of Tirofiban Hydrochloride |
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| LIU Chao,LU Xu-fang,GENG Yuan-shuo,LI Zhi-yu.Synthesis of Tirofiban Hydrochloride[J].Fine Chemical Intermediates,2013(2):42-45,65. |
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| Authors: | LIU Chao LU Xu-fang GENG Yuan-shuo LI Zhi-yu |
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| Affiliation: | (Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | Tirofiban hydrochloride is a reversible non-peptide platelet GP IIb/IIIa receptor antagonist,for the treatment of acute coronary syndrome. This paper reported the synthesis of Tirofiban hydrochloride from 4-（4- piperidinyl）-1-chlorobutane and L-tyrosine via 7 steps of chemical reactions. This new synthesis route with low- toxicity and simple operation has a high yield which is up to 21.6%. The structures of the intermediates and the final product were certified by MS and 1H NMR. |
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| Keywords: | platelet GP IIb / IIIa receptor antagonist Tirofiban hydrochloride synthesis |
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