Comparison of N-Heterocyclic Aromatics Dibenzo[c,g]Carbazole and Dibenz[a,j]Acridine : Metabolism,DNA Binding and Mutation |
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Authors: | David Warshawsky Heather Dowty Weiling Xue Kent Mitchell Joanne Schneider Kathy Ladow |
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Affiliation: | University of Cincinnati, Department of Environmental Health , Cincinnati, Ohio, 45267-0056 |
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Abstract: | N-Heterocyclic aromatics, such as carbazole and acridine derivatives, are environmental carcinogenic pollutants. Examples of these compounds are 7H-dibenzo[c,g]carbazole (DBC) and dibenz[a,j]acridine (DBA). The ionization potential (IP) for DBC is lower than for DBA. DBC is metabolized in lung and liver by way of phenols or directly through radical cations. DBC-induced liver and lung tumors have mutations in the 61st codon of ras. DBA is metabolized in skin by way of a diol-epoxide of DBA. DBA-induced skin tumors have mutations in 12th, 13th and 61st codons of ras. In summary, the metabolic activation of DBC proceeds through different adduction pattern pathways than does DBA and leads to different ras mutational spectra. |
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Keywords: | 7H-dibenzo[c,g]carbazole dibenz[a,j]acridine stable adduction ionization potential ras |
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