| 药物控、缓释体系的缓释同步性研究 |
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| 引用本文： | 徐东,周宁琳,方苏,孟娜,章峻,莫宏,沈健. 药物控、缓释体系的缓释同步性研究[J]. 功能材料, 2010, 41(3) |
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| 作者姓名： | 徐东 周宁琳 方苏 孟娜 章峻 莫宏 沈健 |
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| 作者单位： | 南京师范大学,江苏省生物医药功能材料工程研究中心,江苏,南京,210097;南京师范大学,江苏省生物功能材料重点实验室,江苏,南京,210097;南京师范大学,江苏省生物医药功能材料工程研究中心,江苏,南京,210097;南京师范大学,江苏省生物功能材料重点实验室,江苏,南京,210097;南京大学,江苏省表面与界面工程技术研究中心,江苏,南京,210093 |
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| 基金项目： | 国家自然科学基金资助项目(20874047);;国家高技术研究发展计划(863计划)专项资助项目(2006AA032Z445);;江苏省教育厅基金资助项目(JHB05-21) |
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| 摘 要： | 通过插层技术合成了醋酸洗必泰-盐酸特比萘芬/蒙脱土(CA-TBNF/MMT)药物控、缓释纳米中间体,利用XRD对其结构进行了表征,结果表明CA-TBNF已进入MMT层间,层间距变化明显。最小抑菌浓度与缓释浓度匹配,从层间解析出的CA与TB-NF在协同作用下对细菌和真菌都有较好的杀菌效果。实验证明两种药物可实现同步缓释。
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| 关 键 词： | 醋酸洗必泰 盐酸特比萘芬 蒙脱土 同步缓释 最小抑菌浓度 |
Synchronicity of a controlled drug release system |
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| XU Dong,ZHOU Ning-lin,FANG Su,MENG Na,ZHANG Jun,MO Hong,SHEN Jian. Synchronicity of a controlled drug release system[J]. Journal of Functional Materials, 2010, 41(3) |
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| Authors: | XU Dong ZHOU Ning-lin FANG Su MENG Na ZHANG Jun MO Hong SHEN Jian |
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| Affiliation: | 1.Jiangsu Engineering Research Center for Biomedical Function Materials;Nanjing Normal University;Nanjing 210097;China;2.Jiangsu Key Laboratory of Biofunctional Materials;College of Chemistry and Environmental Science;3.Jiangsu Technological Research Center for Interfacial Chemistry and Chemical Engineering;Nanjing University;Nanjing 210093;China |
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| Abstract: | Chlorhexidine acetate (CA) and terbinafine hydrochloride (TBNF) have been intercalated into montmorillonite (MMT) as a sustained release drug carrier. The structures and property of CA-TBNF/MMT are studied. The results of X-ray diffraction (XRD) show that the ratio (3∶2∶2) of CA∶TBNF∶MMT is suitable which has best intercalation efficiency. The antimicrobial experiment indicates that the CA-TBNF/MMT antibacterial composites possess wonderful antimicrobial activity and the minimal inhibitory concentration (MIC) matches with in vitro release. CA-TBNF/MMT is found to have an antimicrobial effect against E.coli, S.aureus, P.aeruginosa and C.albicans. |
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| Keywords: | chlorhexidine acetate terbinafine hydrochloride montmorillonite synchronous release minimal inhibitory concentration |
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