| ~(60)Coγ射线辐射对淋巴细胞化学发光的生物效应(英文) |
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| 作者单位： | 苏州医学院
(茅子均)，苏州医学院(苏枭) |
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| 摘 要： | 用淋巴细胞化学发光(Ly-CL)技术,研究了离体状况下~(60)Coγ射线辐射对PHA或ConA激发的Ly-CL的生物效应。结果表明:(1)0.25Gy~(60)Coγ射线辐射对PHA(200μg/mL)激发的Ly-CL峰值有增强趋势(P>0.05),0.5Gy有明显增强效应(P<0.05),1～16Gy引起显著或非常显著性抑制(P<0.05或P<0.01)。(2)2～16Gy~(60)Coγ射线辐射对ConA(50、100μg/mL)激发的Ly-CL峰值产生显著或非常显著性抑制作用(P<0.05或 P<0.01)。回归分析表明,峰值下降幅度和辐射剂量间有显著线性关系(P<0.0005)。2～16Gy~(60)Coγ射线辐射对PHA或ConA引起的Ly-CL峰时无影响(P>0.05)。
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| 关 键 词： | 淋巴细胞化学发光 辐射 植物血凝素(PHA) 刀豆蛋白-A(ConA) |
BIOLOGICAL EFFECTS OF ~(80)Co y-RAY IRRADIATION ON LYMPHOCYTE CHEMOLUMINESCENCE |
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| Authors: | Mao Zijun Su Xiao |
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| Affiliation: | SUZHOU MEDICAL COLLEGE |
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| Abstract: | Utilizing lymphocyte chemoluminescence technique, the biological effects of 60Co Y-ray irradiation on lymphocyte chemoluminescence (Ly-CL) stimulated with PHA or ConA in vitro were investigated. The results showed; (1)0. 25 Gy 60Co Y-ray irradiation showed a tendency to increase( P >0. 05) ,0. 5 Gy showed significant increase in Ly-CL( P <0. 05) , 1 Gy produced significant suppression( P <0. 05) ,2-16 Gy led to very significant suppression( P <0. 01). (2)2-16 Gy 60Co Y-ray irradiation also expressed suppressive effects on Ly-CL caused by two different concentration of ConA (50 100 ng/mL)( P <0. 01). Linear regression analysis showed,there was significant correlation between the intensity of Ly-CL and irradiation dose ( P 0. 05). |
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| Keywords: | ~(60)Co y-ray irradiation lymphocyte chemoluminescence Con-canaualin-A phytohemagglutinin |
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