复方参芪冲剂抗肿瘤作用

目的 观察复方参芪冲剂对小鼠S180、H22、Lew is 肿瘤生长及与化疗药物阿霉素(ADM)、顺铂(DDP)、环磷酰胺(CTX)合用对抗肿瘤活性和免疫功能的影响。方法 采用动物移植瘤S180、H22、Lewis 模型, 对复方参芪冲剂的抗肿瘤作用及对化疗药物的增效减毒作用进行检测。结果 复方参芪冲剂对小鼠S180、H22、Lewis 均有明显抑制作用, 明显增强ADM、DDP、CTX 的抗肿瘤活性, 对其所引起的免疫抑制性有明显保护作用。结论 复方参芪冲剂的抗肿瘤作用及对化疗药物的增效解毒作用, 可能是通过增强机体的免疫功能实现的。

Antitumor effect of compound shenqi granule

Aim The influence of the compound Shenqigranule both on the grow th of S 180,H22, Lew is and on the antineo plastic activity as w ell as immunolog ical function in combination with ADM,DDP and CTX was to be observed.Methods Antineoplastic activity of the compound and the sy nergia, detoxi fication of chemotherapy drug s were observed in mouse transplanted tumor models.Results It was revealed that the compound Shenqig ranule Obviously decreaced the tumor of S180, H22, Lew is, increaced the antineoplasticactivity of ADM, DDP, CTX, and prevented the immusuppress induced by ADM, DDPand CTX.Conclusion The compound S henqi g ranule has the properties of ant ineoplast ic function and the synergia and detox ification which result from its enhance of immuno logical function.