Identification of the epitope for a highly cross-reactive monoclonal antibody on the major sigma factor of bacterial RNA polymerase |
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| Authors: | MJ Breyer NE Thompson RR Burgess |
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| Affiliation: | McArdle Laboratory for Cancer Research, University of Wisconsin--Madison, 53706, USA. |
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| Abstract: | A highly cross-reactive monoclonal antibody (MAb), 2G10, was found to react in a conserved region of Escherichia coli RNA polymerase sigma70. The epitope was localized to amino acids 470 to 486, which included part of conserved region 3.1. The epitope for MAb 3D3, a MAb which maps close to the 2G10 epitope, was also determined. |
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